He is most well known for being the lead singer for the AOR bands Sorcery (1980–1983), Giuffria (1983–1988), Dirty White Boy (1988–1991), and Stream (1998). His biggest success came with the band Giuffria, when their hit single "Call to the Heart" reached number 15 on the Billboard Hot 100 in early 1985. Eisley has also appeared in the television shows Beverly Hills, 90210 and 7th Heaven, the movie Action Jackson and has acted in various commercials. Eisley's 1986 rock ballad "Sweet Victory", which was co-created by Bob Kulick and includes Eric Singer on drums, was featured in the 2001 SpongeBob SquarePants episode "Band Geeks" and reached number 23 on the Hot Rock Songs chart in February 2019.